Farmacias take turns to provide an out-of-hours service (at night and for holidays) as the farmacia de guardia. You will be able to find out which one is open by looking in a local paper or in the window of any pharmacy where they usually display a list.
Pharmacists in Spain are more highly-trained than in some countries and will provide treatment advice for many common illnesses and ailments, but they are not a substitute for going to a doctor if there is something really wrong with you.
Spain is a quite unrestrictive when it comes to the distribution of medications that are strictly prescription drugs in other countries (such as antibiotics), so these are commonly available over-the-counter. Medicines tend to cost significantly less than in other countries due to state imposed price restrictions.
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